Sequential Steps of CRAC Channel Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.025
Abstract: Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. How STIM1 binds and activates ORAI1 remains poorly understood. Using electrophysiological, optical,… read more here.
Keywords: orai1; steps crac; crac channel; sequential steps ... See more keywords
Olanzapine-induced insulin resistance may occur via attenuation of central KATP channel-activation
Sign Up to like & getrecommendations! Published in 2021 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2020.12.005
Abstract: Antipsychotic use is associated with an increased risk of type 2 diabetes. Recent work suggests antipsychotics can induce insulin resistance immediately and independently of weight gain, and that this may occur via the central nervous… read more here.
Keywords: katp channel; channel; channel activation; olanzapine ... See more keywords
Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33620-7
Abstract: Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of… read more here.
Keywords: trpv1; itch; induced itch; trpv1 expressing ... See more keywords
Sodium channel activation underlies transfluthrin repellency in Aedes aegypti
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0009546
Abstract: Background Volatile pyrethroid insecticides, such as transfluthrin, have received increasing attention for their potent repellent activities in recent years for controlling human disease vectors. It has been long understood that pyrethroids kill insects by promoting… read more here.
Keywords: transfluthrin repellency; channel activation; repellency; sodium channel ... See more keywords
Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00581
Abstract: As an oxidative stress sensor, transient receptor potential melastatin 2 (TRPM2) channel is involved in many physiological and pathological processes including warmth sensing, ischemia injury, inflammatory diseases and diabetes. Intracellular calcium is critical for TRPM2… read more here.
Keywords: trpm2 channel; terminus trpm2; calcium; channel activation ... See more keywords
Tubeimoside I Antagonizes Yoda1-Evoked Piezo1 Channel Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.00768
Abstract: Piezo1, a mechanosensitive Ca2+-permeable non-selective cationic ion channel protein, is involved in a wide range of biological processes and plays crucial roles in vascular development. However, the pharmacology of this protein is in its infancy.… read more here.
Keywords: piezo1; piezo1 channel; yoda1; pharmacology ... See more keywords
Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.28029
Abstract: CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that… read more here.
Keywords: voltage; proximal clustering; cav1 channels; activation ... See more keywords
Possible magneto-mechanical and magneto-thermal mechanisms of ion channel activation in magnetogenetics
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.45807
Abstract: The palette of tools for perturbation of neural activity is continually expanding. On the forefront of this expansion is magnetogenetics, where ion channels are genetically engineered to be closely coupled to the iron-storage protein ferritin.… read more here.
Keywords: ion channel; mechanisms ion; magneto; ion ... See more keywords