The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators
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DOI: 10.3389/fphar.2019.00972
Abstract: Calcium-activated K+ channels constitute attractive targets for the treatment of neurological and cardiovascular diseases. To explain why certain 2-aminobenzothiazole/oxazole-type KCa activators (SKAs) are KCa3.1 selective we previously generated homology models of the C-terminal calmodulin-binding domain… read more here.
Keywords: cam; kca channel; channel activators; structure ... See more keywords