Ilepcimide inhibited sodium channel activity in mouse hippocampal neurons
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106533
Abstract: Ilepcimide (ICM), a clinically effective antiepileptic drug, has been used in China for decades; however, its antiepileptic mechanism remains unclear. ICM is structurally similar to antiepileptic drug lamotrigine (LTG). LTG exerts its anticonvulsant effect by… read more here.
Keywords: channel activity; sodium channel; icm; mouse hippocampal ... See more keywords
Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.05.027
Abstract: As the immunocompetent cells of the central nervous system, microglia accumulate at amyloid beta plaques in Alzheimer's disease (AD) and acquire a morphological phenotype of activated microglia. Recent functional studies, however, indicate that in mouse… read more here.
Keywords: alzheimer disease; potassium channel; channel activity; activity ... See more keywords
Effect of truncation on TRPM7 channel activity.
Sign Up to like & getrecommendations! Published in 2023 at "Channels"
DOI: 10.1080/19336950.2023.2200874
Abstract: Transient receptor potential melastatin-like 7 (TRPM7) is a key player in various physiological and pathological processes. TRPM7 channel activity is regulated by different factors. The effects of cleavage of different domains on channel activity remain… read more here.
Keywords: domain; trpm7 channel; activity; channel activity ... See more keywords
GIRK channel activity in prelimbic pyramidal neurons regulates the extinction of cocaine conditioned place preference in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13256
Abstract: Drug‐induced neuroadaptations in the prefrontal cortex (PFC) have been implicated in drug‐associated memories that motivate continued drug use. Chronic cocaine exposure increases pyramidal neuron excitability in the prelimbic subregion of the PFC (PL), an adaptation… read more here.
Keywords: pyramidal neurons; channel activity; girk channel; cocaine ... See more keywords
Amyloid-beta peptide potentiates vascular Cav1.2 channel activity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5727832
Abstract: Alzheimer’s disease (AD), the most common form of dementia, affects over 6 million Americans and has devastating emotional and physical consequences for both the patient and surrounding loved ones. Current drug therapies are principally targeted… read more here.
Keywords: physiology; vascular cav1; channel activity; cav1 channel ... See more keywords
Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01122
Abstract: ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and… read more here.
Keywords: tolerance; channel activity; katp; katp channel ... See more keywords
Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070954
Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a polymodal Ca2+-permeable channel involved in various hypoxia-sensitive pathophysiological phenomena. Different tools are available to study channel activity, requiring cells to be cultured at specific optimal densities. In… read more here.
Keywords: cell; channel activity; confluence; hypoxia ... See more keywords
Inhibition of SARS-CoV-2 Viral Channel Activity Using FDA-Approved Channel Modulators Independent of Variants
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111673
Abstract: Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and… read more here.
Keywords: channel activity; channel modulators; fda approved; channel ... See more keywords
Bicarbonate-Independent Sodium Conductance of Na/HCO3 Cotransporter NBCn1 Decreases NMDA Receptor Function
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44030086
Abstract: The sodium bicarbonate cotransporter NBCn1 is an electroneutral transporter with a channel activity that conducts Na+ in a HCO3–-independent manner. This channel activity was suggested to functionally affect other membrane proteins which permeate Na+ influx.… read more here.
Keywords: activity; hco3; channel activity; cotransporter nbcn1 ... See more keywords
Mammalian Brain Ca2+ Channel Activity Transplanted into Xenopus laevis Oocytes
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12050496
Abstract: Several mutations on neuronal voltage-gated Ca2+ channels (VGCC) have been shown to cause neurological disorders and contribute to the initiation of epileptic seizures, migraines, or cerebellar degeneration. Analysis of the functional consequences of these mutations… read more here.
Keywords: ca2 channel; channel activity; brain; activity ... See more keywords
Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceuticals"
DOI: 10.3390/ph10020035
Abstract: Two transient receptor potential (TRP) channels—TRPA1 and TRPV3—are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity. The enzymes responsible are the HIF prolyl hydroxylases (PHDs) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). The… read more here.
Keywords: hydroxylation; channel activity; trp channel; modulation trp ... See more keywords