Ilepcimide inhibited sodium channel activity in mouse hippocampal neurons
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106533
Abstract: Ilepcimide (ICM), a clinically effective antiepileptic drug, has been used in China for decades; however, its antiepileptic mechanism remains unclear. ICM is structurally similar to antiepileptic drug lamotrigine (LTG). LTG exerts its anticonvulsant effect by… read more here.
Keywords: channel activity; sodium channel; icm; mouse hippocampal ... See more keywords
Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.05.027
Abstract: As the immunocompetent cells of the central nervous system, microglia accumulate at amyloid beta plaques in Alzheimer's disease (AD) and acquire a morphological phenotype of activated microglia. Recent functional studies, however, indicate that in mouse… read more here.
Keywords: alzheimer disease; potassium channel; channel activity; activity ... See more keywords
Effect of truncation on TRPM7 channel activity.
Sign Up to like & getrecommendations! Published in 2023 at "Channels"
DOI: 10.1080/19336950.2023.2200874
Abstract: Transient receptor potential melastatin-like 7 (TRPM7) is a key player in various physiological and pathological processes. TRPM7 channel activity is regulated by different factors. The effects of cleavage of different domains on channel activity remain… read more here.
Keywords: domain; trpm7 channel; activity; channel activity ... See more keywords
GIRK channel activity in prelimbic pyramidal neurons regulates the extinction of cocaine conditioned place preference in male mice
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13256
Abstract: Drug‐induced neuroadaptations in the prefrontal cortex (PFC) have been implicated in drug‐associated memories that motivate continued drug use. Chronic cocaine exposure increases pyramidal neuron excitability in the prelimbic subregion of the PFC (PL), an adaptation… read more here.
Keywords: pyramidal neurons; channel activity; girk channel; cocaine ... See more keywords
Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice
Sign Up to like & getrecommendations! Published in 2024 at "Science Signaling"
DOI: 10.1126/scisignal.ado4132
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ). The dysregulation of G protein–gated inwardly… read more here.
Keywords: channel; mice; channel activity; girk channel ... See more keywords
Amyloid-beta peptide potentiates vascular Cav1.2 channel activity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5727832
Abstract: Alzheimer’s disease (AD), the most common form of dementia, affects over 6 million Americans and has devastating emotional and physical consequences for both the patient and surrounding loved ones. Current drug therapies are principally targeted… read more here.
Keywords: physiology; vascular cav1; channel activity; cav1 channel ... See more keywords
Impact of CFTR Correctors on the Channel Activity of Rescued F508del CFTR in Airway Epithelial Cells
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.1752
Abstract: Cystic fibrosis (CF) is caused by the functional deficiency of a cAMP-activated anion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR). Over 90% of CF patients carry at least one copy of the… read more here.
Keywords: physiology; f508del; channel activity; cftr ... See more keywords
Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells
Sign Up to like & getrecommendations! Published in 2024 at "Respiratory Research"
DOI: 10.1186/s12931-024-02889-w
Abstract: Background Cystic Fibrosis causing mutations in the gene CFTR , reduce the activity of the CFTR channel protein, and leads to mucus aggregation, airway obstruction and poor lung function. A role for CFTR in the… read more here.
Keywords: cftr channel; airway; channel activity; activity ... See more keywords
Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype KATP Channel Activity in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01122
Abstract: ATP-sensitive potassium (KATP) channels are found in the nervous system and are downstream targets of opioid receptors. KATP channel activity can effect morphine efficacy and may beneficial for relieving chronic pain in the peripheral and… read more here.
Keywords: tolerance; channel activity; katp; katp channel ... See more keywords
Cell Confluence Modulates TRPV4 Channel Activity in Response to Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070954
Abstract: Transient receptor potential vanilloid 4 (TRPV4) is a polymodal Ca2+-permeable channel involved in various hypoxia-sensitive pathophysiological phenomena. Different tools are available to study channel activity, requiring cells to be cultured at specific optimal densities. In… read more here.
Keywords: cell; channel activity; confluence; hypoxia ... See more keywords
Inhibition of SARS-CoV-2 Viral Channel Activity Using FDA-Approved Channel Modulators Independent of Variants
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111673
Abstract: Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and… read more here.
Keywords: channel activity; channel modulators; fda approved; channel ... See more keywords