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   Articles with "channel antagonists" as a keyword



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Chiral separation of calcium channel antagonists by SFC and HPLC using different immobilized chiral stationary phases.

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recommendations! Published in 2022 at "Chirality"

DOI: 10.1002/chir.23410

Abstract: Supercritical fluid chromatography and high-performance liquid chromatography techniques are popular for the chiral separations of different drugs and pharmaceuticals. Therefore, this article describes a comparative study of the chiral separation of some calcium channel antagonists… read more here.

Keywords: separation calcium; channel antagonists; calcium channel; chiral separation ... See more keywords
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Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives

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recommendations! Published in 2019 at "Chemical Research in Chinese Universities"

DOI: 10.1007/s40242-019-8273-8

Abstract: A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoacetate and ethyl 3-aminocrotonate was developed. Operational simplicity, mild reaction conditions and… read more here.

Keywords: synthesis dihydropyridine; synthesis; calcium channel; papain catalyzed ... See more keywords
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Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.173

Abstract: Sepsis is a systemic inflammatory response syndrome triggered by lipopolysaccharide (LPS), an outer membrane component of gram-negative bacteria, and cytokine production via LPS-induced macrophage activation is deeply involved in its pathogenesis. Effective therapy of sepsis… read more here.

Keywords: channel antagonists; cox; expression; trpv1 channel ... See more keywords