Calcium channel blocker lercanidipine electrochemistry using a carbon black–modified glassy carbon electrode
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02591-y
Abstract: Lercanidipine, a third-generation dihydropyridine calcium L-type channel blocker, redox behavior at different carbon electrode materials, in a wide pH range, using cyclic, square-wave, and differential pulse voltammetry, was studied. A comparison was made between unmodified… read more here.
Keywords: glassy carbon; carbon; channel blocker; electrochemistry ... See more keywords
A new and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil
Sign Up to like & getrecommendations! Published in 2017 at "New Journal of Chemistry"
DOI: 10.1039/c6nj02928k
Abstract: A concise and efficient enantioselective synthesis of both enantiomers of bepridil, a calcium channel blocker, is reported. Jacobsen's hydrolytic kinetic resolution method was utilized to resolve racemic 2-(isobutoxymethyl)oxirane. The incorporation of the succinimide moiety by… read more here.
Keywords: efficient enantioselective; calcium channel; channel blocker; synthesis enantiomers ... See more keywords
Supramolecular nanoprodrug based on a chloride channel blocker and glycosylated pillar[5]arenes for targeted chemoresistance cancer therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00233k
Abstract: A supramolecular nanoprodrug (DOX@GP5⊃Pro-NFA) was constructed based on the host-guest complexation of chloride channel blocker prodrug (Pro-NFA) and glycosylated pillar[5]arene (GP5), which could target tumor cells via galactose and release DOX/NFA responsively under esterase stimulation.… read more here.
Keywords: supramolecular nanoprodrug; channel blocker; chloride channel; glycosylated pillar ... See more keywords
A calcium channel blocker, manoalide exerts an anti-allergic inflammatory effect through attenuating NF-κB activity
Sign Up to like & getrecommendations! Published in 2021 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2021.1988101
Abstract: Abstract Background Many people are troubled by allergic inflammation including ocular allergic diseases, anaphylaxis, allergic rhinitis, atopic dermatitis, and eczema. Consequently, finding medications for use in allergic inflammation therapy is crucial in human health. Manoalide,… read more here.
Keywords: calcium channel; channel blocker; anti allergic; manoalide exerts ... See more keywords
Analytical and Bioanalytical Techniques for the Quantification of the Calcium Channel Blocker - Amlodipine: A Critical Review.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in analytical chemistry"
DOI: 10.1080/10408347.2020.1772036
Abstract: Hypertension is a condition in which blood pressure is elevated to an extent where benefit is obtained from blood pressure lowering. The risk of complications is proportional to the level that blood pressure raises. Calcium… read more here.
Keywords: calcium channel; channel blocker; analytical bioanalytical; blood pressure ... See more keywords
A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001638
Abstract: Preclinical studies suggest that type 2 hyperpolarization-activated cyclic nucleotide gated ion channels (HCN2) are necessary for neuropathic pain. This trial assessed the influence of ivabradine, a non-selective HCN channel blocker, on capsaicin-induced hyperalgesia and pain… read more here.
Keywords: trial; hcn channel; channel blocker; placebo ... See more keywords
T-type Ca2+ channel blocker mibefradil blocks ORAI channels via acting on extracellular surface.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14788
Abstract: BACKGROUND AND PURPOSE Mibefradil (Mib), a T-type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on… read more here.
Keywords: channel blocker; mib; channel; ca2 channel ... See more keywords
Pharmacological and mechanical management of calcium channel blocker toxicity
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DOI: 10.1136/bcr-2018-225324
Abstract: Cardiovascular instability associated with calcium channel blocker toxicity comprises a small percentage of overdose presentations, yet they are associated with a high mortality rate. We detail the management of a 64-year-old man who took an… read more here.
Keywords: calcium; calcium channel; channel blocker; blocker toxicity ... See more keywords
Calcium Channel Blocker Toxicity: A Practical Approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Multidisciplinary Healthcare"
DOI: 10.2147/jmdh.s374887
Abstract: Abstract Calcium channel blockers (CCBs) are widely prescribed medications for various clinical indications in adults and children. They are available in both immediate and long-acting formulations and are generally classified into dihydropyridines and nondihydropyridines, with… read more here.
Keywords: calcium; channel blocker; calcium channel; toxicity ... See more keywords
Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.940178
Abstract: Hantaviruses, the causative agent for two types of hemorrhagic fevers, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), are distributed from Eurasia to America. HFRS and HPS have mortality rates of up… read more here.
Keywords: entry; calcium channel; channel blocker; hantavirus ... See more keywords
New Charge Transfer Complexes of K+-Channel-Blocker Drug (Amifampridine; AMFP) for Sensitive Detection; Solution Investigations and DFT Studies
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26196037
Abstract: UV–Vis spectroscopy was used to investigate two new charge transfer (CT) complexes formed between the K+-channel-blocker amifampridine (AMFP) drug and the two π-acceptors 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) and tetracyanoethylene (TCNE) in different solvents. The molecular composition of… read more here.
Keywords: transfer complexes; new charge; channel blocker; amifampridine amfp ... See more keywords