Evaluation of in vitro effect, molecular docking, and molecular dynamics simulations of some dihydropyridine-class calcium channel blockers on human serum paraoxonase 1 (hPON1) enzyme activity.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2467
Abstract: Paraoxonase 1 (PON1) was purified 148.80-fold in 37.92% yield by hydrophobic interaction chromatography technique. The purity of PON1 was checked by SDS PAGE with a single band of 43 kDa. The in vitro effects of… read more here.
Keywords: molecular docking; channel blockers; calcium channel; molecular dynamics ... See more keywords
Hair analysis for beta‐blockers and calcium‐channel blockers by using liquid chromatography‐tandem mass spectrometry as a tool for monitoring adherence to antihypertensive therapy
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3346
Abstract: Abstract Adherence to therapy is the key to a successful therapeutic intervention, especially in cardiovascular diseases in which a lack of adherence may have serious consequences in terms morbidity and/or mortality. In this context, hair… read more here.
Keywords: adherence; channel blockers; calcium channel; therapy ... See more keywords
L-type calcium channel blockers and a symptom complex mimicking de Melo-Souza’s syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Neurological Sciences"
DOI: 10.1007/s10072-018-3662-1
Abstract: Dear Editor, Drugs are an important cause of tremor in the elderly and the second most common cause of Parkinsonism. Common medications which induce tremor include salbutamol, theophylline, valproate, anti-depressants, anti-psychotics, and anti-dopaminergics [1, 2].… read more here.
Keywords: calcium channel; melo souza; type calcium; channel blockers ... See more keywords
Evaluation of four calcium channel blockers as fluconazole resistance inhibitors in Candida glabrata.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.04.004
Abstract: OBJECTIVES The aim of this study was to evaluate the ability of four calcium channel blockers (CCBs), namely verapamil, diltiazem, nicardipine (NIC) and nifedipine (NIF), to enhance the susceptibility of Candida glabrata strains to fluconazole… read more here.
Keywords: candida glabrata; calcium channel; four calcium; effect ... See more keywords
Calcium Channel blockers are associated with reduced risk of Parkinson's disease in patients with hypertension: A population-based retrospective cohort study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2021.117412
Abstract: BACKGROUND The use of dihydropyridine calcium channel blockers (DCCBs) was proposed to reduce the risk of Parkinson's disease (PD). This study aimed to evaluate the association between DCCB and its dose effect and the risk… read more here.
Keywords: reduced risk; risk; calcium channel; study ... See more keywords
Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of stomatology, oral and maxillofacial surgery"
DOI: 10.1016/j.jormas.2018.02.014
Abstract: The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to… read more here.
Keywords: free flap; calcium channel; channel blockers;
MORTALITY ASSOCIATED WITH CALCIUM CHANNEL BLOCKERS IN HEART FAILURE WITH REDUCED EJECTION FRACTION: REAL WORLD EXPERIENCE
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(18)31013-1
Abstract: Calcium channel blockers (CCB) are associated with a higher risk of mortality in patients with low ejection fraction (EF), but the association between CCB and mortality in patients with AF is not clear. This is… read more here.
Keywords: ejection fraction; calcium channel; channel blockers; mortality ... See more keywords
ACUTE RATE CONTROL OF ATRIAL FIBRILLATION WITH RAPID VENTRICULAR RESPONSE USING INTRAVENOUS CALCIUM CHANNEL BLOCKERS OR INTRAVENOUS BETA BLOCKERS LEADS TO CARDIOGENIC SHOCK IN PATIENTS WITH UNDERLYING SYSTOLIC DYSFUNCTION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)31471-6
Abstract: Intravenous (IV) boluses of nondihydropyridine calcium channel blockers (CCBs) or beta-blockers (B-blockers) are often used for acute rate control in patients with atrial fibrillation (AF) with rapid ventricular response (RVR). However, due to their negative… read more here.
Keywords: atrial fibrillation; rate control; calcium channel; acute rate ... See more keywords
Microscopic Screening of Cyclodextrin Channel Blockers by DiffusiOptoPhysiology.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c02775
Abstract: Blockers of pore-forming toxins (PFTs) limit bacterial virulence by blocking relevant channel proteins. However, screening of desired blockers from a large pool of candidate molecules is not a trivial task. Acknowledging its advantages of low… read more here.
Keywords: screening cyclodextrin; microscopic screening; channel; cyclodextrin channel ... See more keywords
Predicting hERG channel blockers with directed message passing neural networks
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra07956e
Abstract: Compounds with human ether-à-go-go related gene (hERG) blockade activity may cause severe cardiotoxicity. Assessing the hERG liability in the early stages of the drug discovery process is important, and the in silico methods for predicting… read more here.
Keywords: predicting herg; herg; message passing; channel blockers ... See more keywords
Calcium channel blockers potentiate gemcitabine chemotherapy in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200143119
Abstract: Significance Pancreatic cancer is a leading cause of cancer-related death, in part due to incomplete responses to standard-of-care chemotherapy. In this study, using a combination of single-cell RNA sequencing and high-throughput proteomics, we identified the… read more here.
Keywords: pancreatic cancer; channel blockers; calcium channel; gemcitabine chemotherapy ... See more keywords