Tissue-specific adrenergic regulation of the L-type Ca2+ channel CaV1.2.
Sign Up to like & getrecommendations! Published in 2020 at "Science signaling"
DOI: 10.1126/scisignal.abc6438
Abstract: Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to… read more here.
Keywords: channel cav1; ca2 channel; cav1; type ca2 ... See more keywords
β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023404
Abstract: Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathways without affecting organism-wide… read more here.
Keywords: channel cav1; pharmacology; ca2 channel; type ca2 ... See more keywords
Atomic Mechanisms of Timothy Syndrome-Associated Mutations in Calcium Channel Cav1.2
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.00335
Abstract: Timothy syndrome (TS) is a very rare multisystem disorder almost exclusively associated with mutations G402S and G406R in helix IS6 of Cav1.2. Recently, mutations R518C/H in helix IIS0 of the voltage sensing domain II (VSD-II)… read more here.
Keywords: state; timothy syndrome; channel cav1; aid ... See more keywords