Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole.
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DOI: 10.1016/j.str.2020.12.007
Abstract: The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization. Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical industry. The three-dimensional structure of the hERG channel was recently… read more here.
Keywords: herg channel; channel; channel complexed; structure ... See more keywords