Multivalent Inhibitors of Channel-Forming Bacterial Toxins.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2016_20
Abstract: Rational design of multivalent molecules represents a remarkable modern tool to transform weak non-covalent interactions into strong binding by creating multiple finely-tuned points of contact between multivalent ligands and their supposed multivalent targets. Here, we… read more here.
Keywords: multivalent inhibitors; inhibitors channel; channel forming; bacterial toxins ... See more keywords
Electrophysiology on Channel-Forming Proteins in Artificial Lipid Bilayers: Next-Generation Instrumentation for Multiple Recordings in Parallel.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0818-0_4
Abstract: Artificial lipid bilayers have been used for several decades to study channel-forming pores and ion channels in membranes. Until recently, the classical two-chamber setups have been primarily used for studying the biophysical properties of pore… read more here.
Keywords: electrophysiology channel; lipid bilayers; proteins artificial; channel forming ... See more keywords
Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06755
Abstract: Polytheonamide B (1) is a unique peptide natural product because of its extremely complex structure, a channel-forming ability in vitro, and the extremely potent cytotoxicity. The 48-mer sequence of 1 comprises alternating d,l-amino acids and… read more here.
Keywords: mer peptide; solid phase; channel; total synthesis ... See more keywords
Structure and mechanism for iterative amide N-methylation in the biosynthesis of channel-forming peptide cytotoxins
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116578119
Abstract: Significance The channel-forming proteusins are bacterial helical peptides that allow permeation of positively charged ions to influence membrane potential and cellular physiology. We biochemically characterize the effect of two critical posttranslational modifications on the secondary… read more here.
Keywords: structure mechanism; iterative amide; mechanism iterative; channel forming ... See more keywords
Ca2+ channel-forming ORAI proteins: cancer foes or cancer allies?
Sign Up to like & getrecommendations! Published in 2019 at "Experimental oncology"
DOI: 10.32471/exp-oncology.2312-8852.vol-41-no-3.13473
Abstract: The ORAI family of ion channel-forming proteins in mammals includes three members, ORAI1, ORAI2 and ORAI3, encoded by homologous genes. Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry… read more here.
Keywords: orai proteins; channel forming; ca2; entry ... See more keywords
Rotational Dynamics of The Transmembrane Domains Play an Important Role in Peptide Dynamics of Viral Fusion and Ion Channel Forming Proteins—A Molecular Dynamics Simulation Study
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040699
Abstract: Focusing on the transmembrane domains (TMDs) of viral fusion and channel-forming proteins (VCPs), experimentally available and newly generated peptides in an ideal conformation of the S and E proteins of severe acute respiratory syndrome coronavirus… read more here.
Keywords: channel; fusion; forming proteins; viral fusion ... See more keywords