General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02115
Abstract: Under the known pharmacological activation mechanisms, activators allosterically or directly open potassium channel gates. However, herein, molecular dynamics simulations on TREK-1, a member of the channel class gated at the filter, suggested that negatively charged… read more here.
Keywords: pharmacological activation; activation mechanism; channel gates; mechanism ... See more keywords