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Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.639
Abstract: Transient potential receptor ion channel vanilloid member 1, TRPV1, was initially identified as the capsaicin receptor, but is also modulated by various chemical and physical stimuli including elevated temperature, acidic pH, endogenous ligands and regulatory…
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Keywords:
trpv1;
emerging role;
role human;
trpv1 sensing ... See more keywords
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1
Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.04.002
Abstract: Transient receptor potential (TRP) channels are cation channels which participate in a wide variety of physiological processes in organisms ranging from fungi to humans. They fulfill roles in body homeostasis, are sensors for noxious chemicals…
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Keywords:
linker gearbox;
trp channel;
trp;
channel ... See more keywords
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Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.12.022
Abstract: ABSTRACT Voltage‐gated calcium channels (VGCCs) are critical regulators of many cellular functions, including the activity‐dependent release of chemical neurotransmitter from nerve terminals. At nerve terminals, the Cav2 family of VGCCs are closely positioned with neurotransmitter‐containing…
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Keywords:
gating modifiers;
calcium channel;
calcium;
activity ... See more keywords
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2
Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c01879
Abstract: Channelrhodopsins (ChRs) are light-gated ion channels and central optogenetic tools that can control neuronal activity with high temporal resolution at the single-cell level. Although their application in optogenetics has rapidly progressed, it is unsolved how…
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Keywords:
retinal chromophore;
c1c2;
twisting protonation;
chromophore ... See more keywords
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2
Published in 2023 at "Physics in Medicine and Biology"
DOI: 10.1088/1361-6560/acbf9c
Abstract: Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane induces membrane displacement statistics that deviate from Brownian motion. The membrane dynamics from ion channel gating were imaged by phase-sensitive optical coherence microscopy.…
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Keywords:
phase sensitive;
channel gating;
ion channel;
membrane ... See more keywords
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0
Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14141
Abstract: Rescue of F508del‐cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the most common CF mutation, requires small molecules that overcome protein processing, stability and channel gating defects. Here, we investigate F508del‐CFTR rescue by CFFT‐004, a small…
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Keywords:
protein processing;
rescue f508del;
channel gating;
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1
Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010315
Abstract: The large conductance voltage- and Ca2+-activated K+ channels from the inner mitochondrial membrane (mitoBK) are modulated by a number of factors. Among them flavanones, including naringenin (Nar), arise as a promising group of mitoBK channel…
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Keywords:
extent naringenin;
membrane;
mitobk;
channel gating ... See more keywords
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2
Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1033434
Abstract: Transient receptor potential melastatin 2 (TRPM2), a non-selective cation channel, is involved in many physiological and pathological processes, including temperature sensing, synaptic plasticity regulation, and neurodegenerative diseases. However, the gating mechanism of TRPM2 channel is…
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Keywords:
key residues;
transient receptor;
e829 r845;
channel gating ... See more keywords
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Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.762175
Abstract: The large conductance Ca2+-activated potassium (BK) channel is activated by both membrane potential depolarization and intracellular Ca2+ with distinct mechanisms. Neural physiology is sensitive to the function of BK channels, which is shown by the…
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Keywords:
channel mutations;
channel;
physiology;
gating mechanisms ... See more keywords
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1
Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21144938
Abstract: The Calmodulin-Cork gating model is based on evidence for the direct role of calmodulin (CaM) in channel gating. Indeed, chemical gating of cell-to-cell channels is sensitive to nanomolar cytosolic calcium concentrations [Ca2+]i. Calmodulin inhibitors and…
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Keywords:
cam;
cam cork;
cork;
calmodulin cork ... See more keywords