Chloride channel inhibition improves neuromuscular function under conditions mimicking neuromuscular disorders
Sign Up to like & getrecommendations! Published in 2021 at "Acta Physiologica"
DOI: 10.1111/apha.13690
Abstract: The skeletal muscle Cl− channels, the ClC‐1 channels, stabilize the resting membrane potential and dampen muscle fibre excitability. This study explored whether ClC‐1 inhibition can recover nerve‐stimulated force in isolated muscle under conditions of compromised… read more here.
Keywords: inhibition improves; inhibition; channel inhibition; chloride channel ... See more keywords
Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole.
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202153233
Abstract: TRPV3, a representative of the vanilloid subfamily of TRP channels, is predominantly expressed in skin keratinocytes and has been implicated in cutaneous sensation and associated with numerous skin pathologies and cancers. TRPV3 is inhibited by… read more here.
Keywords: structural mechanism; mechanism trpv3; inhibition; channel inhibition ... See more keywords