Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of pharmacology"
DOI: 10.1111/bph.15267
Abstract: BACKGROUND The TRPV4 cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting pharmacological target with therapeutic potential. However, little is known about the… read more here.
Keywords: channel modulators; inhibition; channel; trpv4 ... See more keywords
KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Current Neuropharmacology"
DOI: 10.2174/1570159x15666170630164226
Abstract: Background The intermediate-conductance Ca2+-activated K+ channel KCa3.1 is widely expressed in cells of the immune system such as T- and B-lymphocytes, mast cells, macrophages and microglia, but also found in dedifferentiated vascular smooth muscle cells,… read more here.
Keywords: channel modulators; kca3 channel; compounds glioblastoma; therapeutic compounds ... See more keywords
Inhibition of SARS-CoV-2 Viral Channel Activity Using FDA-Approved Channel Modulators Independent of Variants
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DOI: 10.3390/biom12111673
Abstract: Background: SARS-CoV-2 has undergone mutations, yielding clinically relevant variants. Hypothesis: We hypothesized that in SARS-CoV-2, two highly conserved Orf3a and E channels directly related to the virus replication were a target for the detection and… read more here.
Keywords: channel activity; channel modulators; fda approved; channel ... See more keywords