Akinesia and freezing caused by Na+ leak‐current channel (NALCN) deficiency corrected by pharmacological inhibition of K+ channels and gap junctions
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DOI: 10.1002/cne.24119
Abstract: The Na+ leak‐current channel (NALCN) regulates locomotion, respiration, and intellectual development. Previous work highlighted striking similarities between characteristic movement phenotypes of NALCN‐deficient animals (Drosophila and Caenorhabditis elegans) and the major symptoms of Parkinson's disease and… read more here.
Keywords: gap junctions; channels gap; channel nalcn; leak current ... See more keywords