Knockdown of rno_circRNA_009194 Improves Outcomes in Traumatic Brain Injury Rats Through Inhibiting Voltage-gated Sodium Channel Nav1.3.
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DOI: 10.1089/neu.2020.7520
Abstract: Excessive activation of voltage-gated sodium channel Nav1.3 has been recently reported in secondary traumatic brain injury (TBI). However, the molecular mechanisms underlying regulating voltage-gated sodium channel (Nav1.3) has not been well understood. The present study… read more here.
Keywords: circrna 009194; sodium channel; channel nav1; brain ... See more keywords
Calcium‐dependent Nedd4‐2 upregulation mediates degradation of the cardiac sodium channel Nav1.5: implications for heart failure
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DOI: 10.1111/apha.12872
Abstract: Reductions in voltage‐gated sodium channel (Nav1.5) function/expression provide a slowed‐conduction substrate for cardiac arrhythmias. Nedd4‐2, which is activated by calcium, post‐translationally modulates Nav1.5. We aim to investigate whether elevated intracellular calcium ([Ca2+]i) reduces Nav1.5 through… read more here.
Keywords: calcium; sodium channel; heart failure; channel nav1 ... See more keywords
Local Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine
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DOI: 10.2147/jep.s375349
Abstract: Introduction Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ) are successfully deployed for different diseases beyond the prophylaxis and treatment of malaria. Both substances exhibit antiviral properties and have been proposed for prophylaxis and treatment of… read more here.
Keywords: cardiac channel; inhibition; anesthetic like; local anesthetic ... See more keywords
General mechanism of spider toxin family I acting on sodium channel Nav1.7
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DOI: 10.24272/j.issn.2095-8137.2022.185
Abstract: Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin (NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., N-terminal, loops 1–4, and C-terminal. Here,… read more here.
Keywords: spider toxin; channel nav1; family; nasptx family ... See more keywords
Life Cycle of the Cardiac Voltage-Gated Sodium Channel NaV1.5
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DOI: 10.3389/fphys.2020.609733
Abstract: Cardiac voltage-gated sodium channel NaV1.5, encoded by SCN5A, is crucial for the upstroke of action potential and excitation of cardiomyocytes. NaV1.5 undergoes complex processes before it reaches the target membrane microdomains and performs normal functions.… read more here.
Keywords: voltage gated; cardiac voltage; sodium channel; gated sodium ... See more keywords
Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5
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DOI: 10.3390/ijms23042225
Abstract: The cardiac sodium ion channel (NaV1.5) is a protein with four domains (DI-DIV), each with six transmembrane segments. Its opening and subsequent inactivation results in the brief rapid influx of Na+ ions resulting in the… read more here.
Keywords: mouth; channel pore; site; cardiac sodium ... See more keywords