Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1–4 channels
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DOI: 10.1080/19336950.2016.1213930
Abstract: ABSTRACT Large conductance, voltage and Ca2+ activated K+ channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth muscle tone and neuronal excitability. Their dysfunction is implicated in various diseases… read more here.
Keywords: channels differential; efficacy goslo; goslo compounds; differential efficacy ... See more keywords
Mitochondrial BK Channel Openers CGS7181 and CGS7184 Exhibit Cytotoxic Properties
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DOI: 10.3390/ijms19020353
Abstract: Potassium channel openers (KCOs) have been shown to play a role in cytoprotection through the activation of mitochondrial potassium channels. Recently, in several reports, a number of data has been described as off-target actions for… read more here.
Keywords: openers cgs7181; channel; channel openers; rat brain ... See more keywords