N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9598-8
Abstract: The P2X7 receptor is a frequently studied member of the purinergic receptor family signalling via channel opening and membrane pore formation. Fluorescent imaging is an important molecular method for studying cellular receptor expression and localization.… read more here.
Keywords: human p2x7; channel opening; receptor; p2x7 receptor ... See more keywords
Calcium Channel Opening Rather than the Release of ATP Causes the Apoptosis of Osteoblasts Induced by Overloaded Mechanical Stimulation
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000477592
Abstract: Background: Stress fracture is one of the most common overuse injuries in athletes. Overloaded mechanical stimulation is an important factor affecting stress fractures, but the mechanism is unclear. Methods: MC3T3-E1 cells and a polycaprolactone (PCL)… read more here.
Keywords: intracellular calcium; apoptosis; calcium channel; channel opening ... See more keywords
Subunit promotion energies for channel opening in heterotetrameric olfactory CNG channels
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010376
Abstract: Cyclic nucleotide-gated (CNG) ion channels of olfactory sensory neurons contain three types of homologue subunits, two CNGA2 subunits, one CNGA4 subunit and one CNGB1b subunit. Each subunit carries an intracellular cyclic nucleotide binding domain (CNBD)… read more here.
Keywords: channel opening; energies channel; subunit promotion; promotion energies ... See more keywords
The Mechanism of the Channel Opening in Channelrhodopsin-2: A Molecular Dynamics Simulation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065667
Abstract: Channelrhodopsin-2 (ChR2) has been one of the most important objects in the study of optogenetics. The retinal chromophore molecule absorbs photons and undergoes an isomerization reaction, which triggers the photocycle, resulting in a series of… read more here.
Keywords: channel opening; mechanism; molecular dynamics; channelrhodopsin ... See more keywords