Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23482-5
Abstract: Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood. Here, we examine the role… read more here.
Keywords: stiffness; piezo1; macrophage polarization; polarization ... See more keywords
Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.976482
Abstract: Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the mechanically activated cation channel Piezo1 in macrophages to induce subsequent immune responses. However, the mechanism by which the mechanosensitive signals shape the… read more here.
Keywords: promotes aerobic; activation promotes; piezo1 activation; aerobic glycolysis ... See more keywords