A potassium channel β-subunit couples mitochondrial electron transport to sleep
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1034-5
Abstract: The essential but enigmatic functions of sleep1,2 must be reflected in molecular changes sensed by the brain’s sleep-control systems. In the fruitfly Drosophila, about two dozen sleep-inducing neurons3 with projections to the dorsal fan-shaped body… read more here.
Keywords: potassium channel; potassium; mitochondrial electron; channel subunit ... See more keywords
Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-1595
Abstract: There remains a paucity of functional biomarkers in gastric cancer. Here, we report the identification of the sodium channel subunit SCNN1B as a candidate biomarker in gastric cancer. SCNN1B mRNA expression was silenced commonly by… read more here.
Keywords: gastric cancer; sodium channel; channel subunit; cancer ... See more keywords
A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008943
Abstract: The acoustic startle response is an evolutionarily conserved avoidance behavior. Disruptions in startle behavior, particularly startle magnitude, are a hallmark of several human neurological disorders. While the neural circuitry underlying startle behavior has been studied… read more here.
Keywords: magnitude; startle behavior; channel subunit; forward genetic ... See more keywords
Phylogenetic relationships of the supercontig of sodium channel subunit I (NaV) in 17 species of Anopheles (Diptera: Culicidae)
Sign Up to like & getrecommendations! Published in 2022 at "Revista da Sociedade Brasileira de Medicina Tropical"
DOI: 10.1590/0037-8682-0701-2021
Abstract: ABSTRACT Background: Malaria is a global health problem and is transmitted by the Anopheles species. Due to the epidemiological importance of the genus, studies on biological, phylogenetic, and evolutionary aspects have contributed to the understanding… read more here.
Keywords: relationships supercontig; supercontig sodium; channel subunit; sodium channel ... See more keywords
Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00040
Abstract: Voltage-gated sodium (Nav) channels form the basis for the initiation of the action potential in excitable cells by allowing sodium ions to pass through the cell membrane. The Nav channel α subunit is known to… read more here.
Keywords: voltage; computational investigation; channel subunit; subunit ... See more keywords
The Sweetpotato Voltage-Gated K+ Channel β Subunit, KIbB1, Positively Regulates Low-K+ and High-Salinity Tolerance by Maintaining Ion Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13061100
Abstract: Voltage-gated K+ channel β subunits act as a structural component of Kin channels in different species. The β subunits are not essential to the channel activity but confer different properties through binding the T1 domain… read more here.
Keywords: voltage gated; gated channel; high salinity; channel subunit ... See more keywords