Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity
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DOI: 10.7554/elife.51185
Abstract: Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels… read more here.
Keywords: renal risk; risk; active channels; channels plasma ... See more keywords