Cell‐Penetrating Chaperone Peptide Prevents Protein Aggregation and Protects against Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700095
Abstract: Many of the newly discovered therapeutic peptides and molecules are limited by their inability to cross the cell membrane. In the present study, a cell‐penetrating peptide (CPP), VPTLK, derived from Ku70 protein, is employed to… read more here.
Keywords: peptide; cell; cell penetrating; protein aggregation ... See more keywords
Phenylalanine hydroxylase variants interact with the co‐chaperone DNAJC12
Sign Up to like & getrecommendations! Published in 2019 at "Human Mutation"
DOI: 10.1002/humu.23712
Abstract: DNAJC12, a type III member of the HSP40/DNAJ family, has been identified as the specific co‐chaperone of phenylalanine hydroxylase (PAH) and the other aromatic amino acid hydroxylases. DNAJ proteins work together with molecular chaperones of… read more here.
Keywords: pah; dnajc12; chaperone; phenylalanine hydroxylase ... See more keywords
The co‐chaperone BAG3: Orchestrator of the cellular task force in response to stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30212
Abstract: We and other research teams have been conducting studies on BAG3 protein for several years. BAG3 was first described as a co‐chaperone of HSP70 in 1999 (by Takayama et al. DOI: 10.1074/jbc.274.2.781) and its interactions… read more here.
Keywords: cancer; bag3; 1002 jcb; cell ... See more keywords
Structural and biochemical insights into FKBP51 as a Hsp90 co-chaperone.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30384
Abstract: The FK506-binding protein 51 (FKBP51) is a high-molecular-weight immunophilin that emerged as an important drug target for stress-related disorders, chronic pain, and obesity. It has been implicated in a plethora of molecular pathways but remains… read more here.
Keywords: fkbp51 hsp90; insights fkbp51; biochemical insights; chaperone ... See more keywords
Strong increase of leukocyte apha‐galactosidase A activity in two male patients with Fabry disease following oral chaperone therapy
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.894
Abstract: Fabry disease (OMIM 301500) is an X‐linked disorder caused by alpha‐galactosidase A (α‐Gal A) deficiency. The administration of a pharmacologic chaperone (migalastat) in Fabry patients with amenable mutations has been reported to improve or stabilize… read more here.
Keywords: fabry disease; increase; galactosidase; chaperone ... See more keywords
Plasticity and transient binding are key ingredients of the periplasmic chaperone network
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3641
Abstract: SurA, Skp, FkpA, and DegP constitute a chaperone network that ensures biogenesis of outer membrane proteins (OMPs) in Gram‐negative bacteria. Both Skp and FkpA are holdases that prevent the self‐aggregation of unfolded OMPs, whereas SurA… read more here.
Keywords: network; skp fkpa; chaperone network; plasticity transient ... See more keywords
Structural and functional analysis of the Hsp70/Hsp40 chaperone system
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3725
Abstract: As one of the most abundant and highly conserved molecular chaperones, the 70‐kDa heat shock proteins (Hsp70s) play a key role in maintaining cellular protein homeostasis (proteostasis), one of the most fundamental tasks for every… read more here.
Keywords: chaperone system; structural functional; chaperone; functional analysis ... See more keywords
Calnexin/Calreticulin and Assays Related to N-Glycoprotein Folding In Vitro.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0430-4_29
Abstract: Calnexin (CNX) and calreticulin (CRT) are ER-resident lectin-like molecular chaperones involved in the quality control of secretory or membrane glycoproteins. They can exert molecular chaperone functions via specific binding to the early processing intermediates of… read more here.
Keywords: calnexin calreticulin; calnexin; calreticulin; cnx crt ... See more keywords
Optimizing Chaperone Removal Strategy from Overexpressed Recombinant Proteins : GNE, a Case Study.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1859-2_20
Abstract: In the last two decades, numerous innovative advances, strategies and protocols have been developed and optimized to improve the quality and quantity of soluble recombinant protein production in E. coli. One of the major challenges… read more here.
Keywords: chaperone; removal; protein; chaperone removal ... See more keywords
Measurement of Chaperone-Mediated Effects on Polyglutamine Protein Aggregation by the Filter Trap Assay.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7477-1_5
Abstract: The formation of aggregates by polyglutamine-containing (polyQ) proteins in neurons is a key to the pathogenesis of several progressive neurodegenerative diseases such as Huntington's disease (HD) spinocerebellar ataxias (SCAs), and spinal and bulbar muscular atrophy… read more here.
Keywords: trap assay; filter trap; chaperone; polyq ... See more keywords
Co-Expression of a Thermally Stable and Methanol-Resistant Lipase and Its Chaperone from Burkholderia cepacia G63 in Escherichia coli
Sign Up to like & getrecommendations! Published in 2020 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-020-03453-0
Abstract: Biodiesel biosynthesis with enzymatic transesterification is considered green, sustainable, and environmentally friendly method. Lipase from Burkholderia cepacia G63 has excellent catalytic properties in biodiesel production. Lipase chaperones promote secretion and folding of enzymes, thereby enhancing… read more here.
Keywords: burkholderia cepacia; cepacia g63; escherichia coli; lipase ... See more keywords