Necdin regulates BMAL1 stability and circadian clock through SGT1-HSP90 chaperone machinery
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa601
Abstract: Abstract Circadian clocks are endogenous oscillators that control ∼24-hour physiology and behaviors in virtually all organisms. The circadian oscillator comprises interconnected transcriptional and translational feedback loops, but also requires finely coordinated protein homeostasis including protein… read more here.
Keywords: chaperone machinery; sgt1 hsp90; necdin; circadian clock ... See more keywords
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2017.00724
Abstract: The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading aberrant proteins. Tau, a microtubule associated protein, aberrantly accumulates in… read more here.
Keywords: hsp90 chaperone; chaperone machinery; protein; tau ... See more keywords