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   Articles with "chaperone mediated" as a keyword



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Inhibition of chaperone-mediated autophagy prevents glucotoxicity in the Caenorhabditis elegans mev-1 mutant by activation of the proteasome.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.01.043

Abstract: Chronic hyperglycemia is a hallmark of diabetes mellitus and the main cause of diabetes-associated complications. Increased intracellular glucose levels lead to damaged proteins and in consequence disturb cellular proteostasis. As an important contributor to the… read more here.

Keywords: mev mutant; mediated autophagy; glucotoxicity; chaperone mediated ... See more keywords
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Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy.

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recommendations! Published in 2021 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2021.114899

Abstract: The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of Parkinson's disease (PD). Several preclinical studies have shown α-syn aggregation, and particularly the… read more here.

Keywords: syn; kyp 2047; chaperone mediated; mediated autophagy ... See more keywords
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Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.

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recommendations! Published in 2021 at "Developmental cell"

DOI: 10.1016/j.devcel.2021.06.011

Abstract: Lysosomes are the recycling center and nutrient signaling hub of the cell. Here, we show that lysosomes also control mesenchymal stem cell (MSC) differentiation by proteomic reprogramming. The chaperone-mediated autophagy (CMA) lysosome subgroup promotes osteogenesis,… read more here.

Keywords: vangl2; mediated autophagy; chaperone mediated; differentiation ... See more keywords
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Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells

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recommendations! Published in 2019 at "Cell Death Discovery"

DOI: 10.1038/s41420-019-0206-2

Abstract: Pancreatic ductal adenocarcinoma (PDAC) shows a high level of basal autophagy. Here we investigated the role of optineurin (OPTN) in PDAC cell lines, which is a prominent member of the autophagy system. To that purpose,… read more here.

Keywords: mediated autophagy; chaperone mediated; pdac; cell ... See more keywords
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Monitoring spatiotemporal changes in chaperone-mediated autophagy in vivo

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-019-14164-4

Abstract: Autophagy malfunctioning occurs in multiple human disorders, making attractive the idea of chemically modulating it with therapeutic purposes. However, for many types of autophagy, a clear understanding of tissue-specific differences in their activity and regulation… read more here.

Keywords: mediated autophagy; chaperone mediated; vivo; spatiotemporal changes ... See more keywords
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Glioblastoma ablates pericytes antitumor immune function through aberrant up-regulation of chaperone-mediated autophagy

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1903542116

Abstract: Significance Glioblastoma (GB) is the most lethal brain malignancy without an effective treatment. In this study, we demonstrate that tumor-induced change in chaperone-mediated autophagy (CMA) in host perivascular cells is a targetable process to prevent… read more here.

Keywords: tumor; chaperone mediated; cma; interaction ... See more keywords
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Targetome analysis of chaperone-mediated autophagy in cancer cells

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2019.1586255

Abstract: ABSTRACT Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway of select soluble proteins. Nearly one-third of the soluble proteins are predicted to be recognized by this pathway, yet only a minor fraction of this proteome… read more here.

Keywords: mediated autophagy; chaperone mediated; translation; cancer cells ... See more keywords
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Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics

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recommendations! Published in 2020 at "Autophagy"

DOI: 10.1080/15548627.2020.1848128

Abstract: ABSTRACT As a highly dynamic organelle, mitochondria undergo constant fission and fusion to change their morphology and function, coping with various stress conditions. Loss of the balance between fission and fusion leads to impaired mitochondria… read more here.

Keywords: mediated autophagy; chaperone mediated; marchf5; ubiquitin ligase ... See more keywords
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Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis

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recommendations! Published in 2021 at "Autophagy"

DOI: 10.1080/15548627.2021.1935007

Abstract: ABSTRACT Different types of autophagy co-exist in all mammalian cells, however, the specific contribution of each of these autophagic pathways to the maintenance of cellular proteostasis and cellular function remains unknown. In this work, we… read more here.

Keywords: autophagy gatekeeper; mediated autophagy; chaperone mediated; proteostasis ... See more keywords
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Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2063004

Abstract: ABSTRACT Impaired degradation of the transcriptional coactivator YAP1 and IL6ST (interleukin 6 cytokine family signal transducer), two proteins deregulated in liver cancer, has been shown to promote tumor growth. Here, we demonstrate that YAP1 and… read more here.

Keywords: cma; il6st; mediated autophagy; chaperone mediated ... See more keywords
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Intrinsic role of chaperone-mediated autophagy in cancer stem cell maintenance

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2069450

Abstract: ABSTRACT Chaperone-mediated autophagy (CMA) is a selective type of autophagy specialized in the individual degradation of targeted proteins. Its impact in any cancer stem cell (CSC) subtype remained elusive. In a recent study, we characterized… read more here.

Keywords: stem cell; cancer stem; mediated autophagy; stem ... See more keywords