New insights into molecular chaperone TRAP1 as a feasible target for future cancer treatments.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117737
Abstract: Tumor necrosis factor receptor-associated protein 1 (TRAP1), a molecular chaperone, is a major member of the mitochondrial heat shock protein 90 (Hsp90) family. Studies have shown that TRAP1 can prevent hypoxia-induced damage to cardiomyocytes, maintain… read more here.
Keywords: chaperone; chaperone trap1; cancer; molecular chaperone ... See more keywords
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis.
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DOI: 10.1016/j.mito.2020.08.001
Abstract: Mitochondria play a central role in regulating cellular energy metabolism. However, the present understanding of mitochondria has changed from its unipotent functions to pluripotent and insists on understanding the role of mitochondria not only in… read more here.
Keywords: mitochondrial chaperone; trap1 cells; metastasis; chaperone trap1 ... See more keywords
Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2021.04.003
Abstract: TRAP1, the mitochondrial isoform of heat shock protein (Hsp)90 chaperones, is a key regulator of metabolism and organelle homeostasis in diverse pathological states. While selective TRAP1 targeting is an attractive goal, classical active-site-directed strategies have… read more here.
Keywords: mitochondrial chaperone; strategies therapeutic; trap1 strategies; chaperone trap1 ... See more keywords