Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency.
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DOI: 10.1080/15548627.2022.2050663
Abstract: The discovery of recurrent mutations in subunits and regulators of the vacuolar-type H+-translocating ATPase (V-ATPase) in follicular lymphoma (FL) highlights a role for macroautophagy/autophagy, amino-acid, and nutrient-sensing pathways in the pathogenesis of this disease. Here,… read more here.
Keywords: chaperone vma21; follicular lymphoma; atpase; vma21 ... See more keywords