An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01080-6
Abstract: The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of the mitochondrial protein quality control system. It is essential for cellular… read more here.
Keywords: hsp10 chaperonin; hsp60 hsp10; chaperonin; mitochondrial matrix ... See more keywords
Cryo-EM Structure of the Novel Viral Chaperonin, Encoded by Gene 228 of Bacteriophage AR9 Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2020 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620017584
Abstract: Chaperonins are some of the most studied families of chaperones. They are multimeric complexes that ensure the proper folding of newly synthesized polypeptide chains and prevent the aggregation of denatured stressed proteins in an ATP-dependent… read more here.
Keywords: structure novel; novel viral; cryo structure; bacteriophage ... See more keywords
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function
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DOI: 10.1038/s42003-021-02203-0
Abstract: T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin… read more here.
Keywords: cct8; biology; chaperonin; maturation selection ... See more keywords
The substrate specificity of eukaryotic cytosolic chaperonin CCT
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DOI: 10.1098/rstb.2017.0192
Abstract: The cytosolic chaperonin CCT (chaperonin containing TCP-1) is an ATP-dependent double-ring protein machine mediating the folding of members of the eukaryotic cytoskeletal protein families. The actins and tubulins are obligate substrates of CCT because they… read more here.
Keywords: specificity eukaryotic; cytosolic chaperonin; chaperonin; cct ... See more keywords
Human Papillomavirus Infection Requires the CCT Chaperonin Complex
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DOI: 10.1128/jvi.01943-20
Abstract: Several of the mechanisms that function during the infection of target cells by HPV particles have been previously described. However, many aspects of this process remain unknown. ABSTRACT Human papillomavirus (HPV) infection is a multistep… read more here.
Keywords: infection; human papillomavirus; hpv; cct chaperonin ... See more keywords
Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation
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DOI: 10.26508/lsa.202201753
Abstract: The crystal structure of the dimeric mtHsp60 from grouper fish has been determined, revealing a symmetrical subunit interaction with an exchanged α-helix connecting the two subunits. This structure provides new insights into the conformational changes… read more here.
Keywords: mthsp60; structure; chaperonin; crystal structures ... See more keywords
Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032018
Abstract: Mutations in genes encoding molecular chaperones, for instance the genes encoding the subunits of the chaperonin CCT (chaperonin containing TCP-1, also known as TRiC), are associated with rare neurodegenerative disorders. Using a classical molecular dynamics… read more here.
Keywords: chaperonin; associated rare; molecular dynamics; cct5 ... See more keywords
In Vivo Incorporation of Photoproteins into GroEL Chaperonin Retaining Major Structural and Functional Properties
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DOI: 10.3390/molecules28041901
Abstract: The incorporation of photoproteins into proteins of interest allows the study of either their localization or intermolecular interactions in the cell. Here we demonstrate the possibility of in vivo incorporating the photoprotein Aequorea victoria enhanced… read more here.
Keywords: photoproteins groel; chaperonin; incorporation photoproteins; vivo incorporation ... See more keywords