The chaperonin TRiC is blocked by native and glycated prion protein.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108319
Abstract: Eukaryotic double-ring chaperonin TRiC is an ATP-dependent protein-folding machine. Most of its substrates are known to form large ordered structures from multiple polypeptide chains. Since these structures are similar to fibrillar and oligomeric forms of… read more here.
Keywords: prion; prion protein; chaperonin tric; forms prion ... See more keywords
Chaperonin TRiC/CCT Participates in Mammarenavirus Multiplication in Human Cells via Interaction with the Viral Nucleoprotein
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.01688-22
Abstract: Host-directed antivirals have gained great interest as an antiviral strategy to counteract the rapid emergence of drug-resistant viruses. The chaperonin TRiC/CCT complex has been involved in the life cycle of several viruses, including dengue, Zika,… read more here.
Keywords: chaperonin tric; multiplication; cct; tric cct ... See more keywords
Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila
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DOI: 10.1371/journal.pgen.1008121
Abstract: Endocycle is a commonly observed cell cycle variant through which cells undergo repeated rounds of genome DNA replication without mitosis. Endocycling cells arise from mitotic cells through a switch of the cell cycle mode, called… read more here.
Keywords: drosophila; mechanisms mes; endocycle; regulatory mechanisms ... See more keywords