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Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b03627
Abstract: The preparation of antibody drug conjugates (ADCs), particularly those containing hydrophobic payloads, may promote aggregate formation. The aggregate (high molecular mass species, HMMS) is an impurity that must be controlled in the final drug substance…
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Keywords:
preparation;
structural characterization;
gemtuzumab ozogamicin;
characterization aggregates ... See more keywords