Characterization of Chromosomal Instability in Glioblastoma
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DOI: 10.3389/fgene.2021.810793
Abstract: Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system (CNS). The poor prognosis of GBM due to resistance to therapy has been associated with high chromosomal instability (CIN). Replication stress is a… read more here.
Keywords: glioblastoma; 251 cells; chromosomal instability; treatment ... See more keywords
Characterization of Chromosomal Breakpoints in 12 Cases with 8p Rearrangements Defines a Continuum of Fragility of the Region
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DOI: 10.3390/ijms23063347
Abstract: Improvements in microarray-based comparative genomic hybridization technology have allowed for high-resolution detection of genome wide copy number alterations, leading to a better definition of rearrangements and supporting the study of pathogenesis mechanisms. In this study,… read more here.
Keywords: cases rearrangements; continuum fragility; rearrangements defines; chromosomal breakpoints ... See more keywords