Functional characterization of 27 CYP3A4 variants on macitentan metabolism in vitro
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DOI: 10.1111/jphp.13153
Abstract: Macitentan is a new choice for pulmonary hypertension treatment which is converted to active metabolite ACT132577 by human cytochrome P450 3A4. Human cytochrome P450 3A4 often occurred gene mutations. Gene polymorphism might cause a variety… read more here.
Keywords: variants macitentan; metabolism; macitentan metabolism; functional characterization ... See more keywords