Synthesis and Structural Characterization of 2'-Deoxy-2'-fluoro-l-uridine Nucleic Acids.
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DOI: 10.1021/acs.orglett.1c01498
Abstract: Despite the development of artificial l-RNA/DNA as therapeutic molecules, the in-depth investigation on their chemical modifications is still limited. Here, we synthesize a chemically derivatized 2'-deoxy-2'-fluoro-l-uridine building block and incorporate it into oligonucleotides. Our thermo-denaturization… read more here.
Keywords: deoxy fluoro; synthesis structural; fluoro uridine; fluoro ... See more keywords