Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.
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DOI: 10.1039/c9cc02052g
Abstract: Biochemical and structural studies provide information on the mode of action of FGF401 as a selective, reversible covalent inhibitor of FGFR4. Kinase and proliferation assays reveal that FGF401 has the ability to overcome gatekeeper mutations… read more here.
Keywords: covalent inhibitor; characterization fgf401; reversible covalent; fgf401 reversible ... See more keywords