Characterization of Gel16 as a Cytochrome P450 in Geldanamycin Biosynthesis and in-silico Analysis for an Endogenous Electron Transport System.
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DOI: 10.4014/jmb.1809.09008
Abstract: Geldanamycin and its derivatives, inhibitors of heat shock protein 90, are considered potent anticancer drugs, although their biosynthetic pathways have not yet been fully elucidated. The key step of conversion of 4,5-dihydrogeldanamycin to geldanamycin was… read more here.
Keywords: cytochrome p450; geldanamycin; redox partners; characterization gel16 ... See more keywords