Generation and characterization of genetically modified pigs with GGTA1/β4GalNT2/CMAH knockout and human CD55/CD47 expression for xenotransfusion studies
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DOI: 10.1038/s41598-024-81730-2
Abstract: Pig red blood cells (pRBCs) represent a promising alternative to address the shortage in transfusion medicine. Nonetheless, a major obstacle to their clinical implementation is immunological rejection. In this study, we generated transgenic pigs expressing… read more here.
Keywords: generation characterization; prbcs; genetically modified; characterization genetically ... See more keywords
Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis
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DOI: 10.1371/journal.pone.0250856
Abstract: Glycolytic metabolism is closely involved in physiological homeostasis and pathophysiological states. Among glycolytic enzymes, phosphoglycerate mutase (PGAM) has been reported to exert certain physiological role in vitro, whereas its impact on glucose metabolism in vivo… read more here.
Keywords: characterization genetically; phosphoglycerate mutase; genetically modified; mice ... See more keywords
Recent advances in the characterization of genetically defined neurons that regulate internal‐state‐dependent taste modification in mice
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DOI: 10.14814/phy2.70106
Abstract: The gustatory system plays an important role in evaluating food quality in animals and humans. While some tastes are intrinsically appetitive, such as sweet, which is elicited from high‐calorie nutrients, the other tastes, such as… read more here.
Keywords: advances characterization; defined neurons; genetically defined; characterization genetically ... See more keywords