Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2021.103710
Abstract: Summary Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel, was conducted by theratyping several CFTR modulators from both potentiator and corrector classes. Intestinal current measurements in rectal biopsies,… read more here.
Keywords: characterization i37r; cftr; mutation; i37r cftr ... See more keywords