CHARACTERIZATION OF IMMUNE CHECKPOINT INHIBITOR-RELATED CARDIOTOXICITY IN LUNG CANCER PATIENTS FROM A RURAL SETTING IN EASTERN NORTH CAROLINA
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)31579-7
Abstract: ICI-related cardiotoxicities (iRCs) are rare however recent literature have described myocarditis, pericardial disorders, cardiomyopathies and arrhythmias as potential fatal adverse effects. The cardiotoxic profile of ICIs is not well defined. Our study aimed to characterize… read more here.
Keywords: checkpoint inhibitor; lung; immune checkpoint; lung cancer ... See more keywords
Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15984
Abstract: Immune checkpoint inhibitors (ICI), such as anti‐PD‐1 monoclonal antibodies, have revolutionized cancer therapy by enhancing the cytotoxic effects of T‐cells against tumours. However, enhanced T‐cell activity also may cause myocarditis and cardiotoxicity. Our understanding of… read more here.
Keywords: induced cardiotoxicity; checkpoint inhibitor; immune checkpoint; cardiotoxicity ... See more keywords
Characterization of the immune tumor microenvironment of HER2-positive breast cancer following treatment with entinostat and immune checkpoint inhibition.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15061
Abstract: e15061Background: HER2+ breast cancers are known to be less-immunogenic and associated with low response rates to immune checkpoint inhibitors (ICIs). A combination of immunosuppressive signals tha... read more here.
Keywords: immune checkpoint; breast; immune tumor; characterization immune ... See more keywords
Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs
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DOI: 10.3390/v14040730
Abstract: (1) Background: Avian influenza viruses (AIVs) promptly evade preexisting immunity by constantly altering the immunodominant neutralizing antibody epitopes (antigenic drift) or by procuring new envelope serotypes (antigenic shift). As a consequence, the majority of antibodies… read more here.
Keywords: broiler hens; immune response; triple h5n1; stalk ... See more keywords