Characterization of Impurities in Therapeutic RNAs at the Single Nucleotide Level.
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DOI: 10.1021/acs.analchem.2c04681
Abstract: The chemistry of guide RNA (gRNA) affects the performance of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing technique. However, the literature is very scarce about the study of gRNA degradation and in… read more here.
Keywords: characterization impurities; nucleotide level; chemistry; rnas single ... See more keywords