Identification and Characterization of the 28-N-Methyltransferase Involved in HSAF Analogue Biosynthesis.
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DOI: 10.1021/acs.biochem.2c00575
Abstract: Polycyclic tetramate macrolactams (PoTeMs) are a family of structurally intriguing bioactive natural products. Although the presence of the N-28 methyl group is known to affect bioactivities of some PoTeMs, the mechanism for this methylation remains… read more here.
Keywords: characterization methyltransferase; identification characterization; methyltransferase; hsaf ... See more keywords
Characterization of a C-methyltransferase from Streptomyces griseoviridis – crystal structure, mechanism, and substrate scope
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DOI: 10.1039/d4sc07300b
Abstract: Despite the presence of pyrroloindoles in many natural products with diverse biological activities, their synthesis remains challenging in terms of stereoselectivity, especially with respect to methylation at the indole C3 position. In the present study,… read more here.
Keywords: characterization methyltransferase; methyltransferase streptomyces; structure; streptomyces griseoviridis ... See more keywords