Identification and characterization of a novel glutaminase inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13319
Abstract: In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyze the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC). Several… read more here.
Keywords: characterization novel; inhibitor; glutaminase; novel glutaminase ... See more keywords
Identification and characterization of a novel esterase from Thauera sp.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1659
Abstract: A novel esterase gene TLip was identified from the strain Thauera sp. and expressed at high levels in Escherichia coli. The TLip protein shared the highest identity (48%) to esterase TesA from Pseudomonas aeruginosa when… read more here.
Keywords: characterization novel; tlip; novel esterase; thauera ... See more keywords
Preclinical pharmacokinetics and ADME characterization of a novel anticancer chalcone, cardamonin.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2128
Abstract: Cardamonin (CRD), a chalconoid obtained from several medicinal plants of Zingiberaceae family, had shown promising potential in cancer prevention and therapy. For further development and better pharmacological elucidation, we performed a series of in vitro… read more here.
Keywords: cardamonin; characterization novel; preclinical pharmacokinetics; pharmacokinetics adme ... See more keywords
Characterization of a novel Hoxa5eGFP mouse line
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.563
Abstract: Hox genes encode transcription factors that are important for establishing the body plan. Hoxa5 is a member of the mammalian Hox5 paralogous group that regulates the patterning and morphology of the cervical‐thoracic region of the… read more here.
Keywords: characterization novel; novel hoxa5egfp; hoxa5egfp mouse; mouse line ... See more keywords
Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12627
Abstract: The majority of patients with pancreatic cancer develops cachexia. The mechanisms underlying cancer cachexia development and progression remain elusive, although tumour‐derived factors are considered to play a major role. Pancreatic tumour organoids are in vitro… read more here.
Keywords: characterization novel; generation initial; pancreatic cancer; initial characterization ... See more keywords
Characterization of a novel xylanase from Aspergillus flavus with the unique properties in production of xylooligosaccharides
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.201800545
Abstract: A novel xylanase from the filamentous fungus Aspergillus flavus was purified and characterized as the β‐1, 4‐endoxylanase (designed as AfXynB) with a molecular mass (32.2 kDa), which is different from all of the previously reported xylanases… read more here.
Keywords: characterization novel; aspergillus flavus; xylanase; novel xylanase ... See more keywords
Identification and characterization of the novel bioactive compounds from microalgae and cyanobacteria for pharmaceutical and nutraceutical applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.202100477
Abstract: Microalgae and cyanobacteria (blue‐green algae) are used as food by humans. They have gained a lot of attention in recent years because of their potential applications in biotechnology. Microalgae and cyanobacteria are good sources of… read more here.
Keywords: characterization novel; bioactive compounds; nutraceutical applications; pharmaceutical nutraceutical ... See more keywords
Development and in‐vitro characterization of a novel fetal vesicoamniotic shunt – The Vortex shunt
Sign Up to like & getrecommendations! Published in 2022 at "Prenatal Diagnosis"
DOI: 10.1002/pd.6096
Abstract: To develop and test a novel vesicoamniotic shunt (VAS) to treat fetal lower urinary tract obstruction (LUTO), decrease dislodgement and optimize shunt deployment in‐vitro. read more here.
Keywords: characterization novel; vitro characterization; development vitro; vesicoamniotic shunt ... See more keywords
Structural and functional characterization of a novel acidophilic 7α‐hydroxysteroid dehydrogenase
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3599
Abstract: 7α‐Hydroxysteroid dehydrogenase (7α‐HSDH) is an NAD(P)H‐dependent oxidoreductase belonging to the short‐chain dehydrogenases/reductases. In vitro, 7α‐HSDH is involved in the efficient biotransformation of taurochenodeoxycholic acid (TCDCA) to tauroursodeoxycholic acid (TUDCA). In this study, a gene encoding… read more here.
Keywords: characterization novel; dehydrogenase; functional characterization; structural functional ... See more keywords
Biochemical and Molecular Characterization of Novel Pararetroviral Promoters in Plants.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9458-8_20
Abstract: Special attention needs to be given to defining and studying the regulatory apparatus of different pararetroviral promoters under various physiological conditions because they have significant sequence heterogeneity and unique distributions of stress-responsive cis-elements. Transcriptional regulation… read more here.
Keywords: characterization novel; pararetroviral promoters; molecular characterization; novel pararetroviral ... See more keywords
Functional characterization of a novel thermophilic exo-arabinanase from Thermothielavioides terrestris
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10806-6
Abstract: Arabinanases from glycoside hydrolase family GH93 are enzymes with exo-activity that hydrolyze the α-1,5 bonds between arabinose residues present on arabinan. Currently, several initiatives aiming to use byproducts rich in arabinan such as pectin and… read more here.
Keywords: characterization novel; thermothielavioides terrestris; exo arabinanase; functional characterization ... See more keywords