Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract
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DOI: 10.1002/cac2.12372
Abstract: Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of… read more here.
Keywords: carcinomas gastrointestinal; neuroendocrine carcinomas; genomic characterization; characterization reveals ... See more keywords
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
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DOI: 10.1016/j.cell.2020.06.013
Abstract: To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and… read more here.
Keywords: lung adenocarcinoma; characterization reveals; therapeutic vulnerabilities; proteogenomic characterization ... See more keywords
Molecular characterization reveals the complexity of previously overlooked coral-exosymbiont interactions and the implications for coral-guild ecology
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DOI: 10.1038/srep44923
Abstract: Several obligate associate crabs and shrimps species may co-occur and interact within a single coral host, leading to patterns of associations that can provide essential ecological services. However, knowledge of the dynamics of interactions in… read more here.
Keywords: reveals complexity; characterization reveals; molecular characterization; complexity ... See more keywords