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Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra04670a
Abstract: Scalable asymmetric syntheses of two kallikrein-related protease 6 (KLK6) inhibitors are reported. The inhibitors are assembled by linking enantiomerically enriched fragments via amide bond formation, followed by conversion of a cyano group to an amidine.…
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Keywords:
characterization reversible;
synthesis structural;
klk6 inhibitors;
scalable synthesis ... See more keywords