The preparation, characterization, structure and dissolution analysis of apremilast solvatomorphs.
Sign Up to like & getrecommendations! Published in 2017 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229617002984
Abstract: Apremilast (AP) {systematic name: (S)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-4-acetamidoisoindoline-1,3-dione} is an inhibitor of phosphodieasterase-4 (PDE4) and is indicated for the treatment of adult patients with active psoriatic arthritis. The ability of AP to form solvates has been investigated and… read more here.
Keywords: characterization structure; analysis; structure dissolution; three solvatomorphs ... See more keywords
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.2210/pdb6dnd/pdb
Abstract: Pancreatic cancer cells are characterized by deregulated metabolic programs that facilitate growth and resistance to oxidative stress. Among these programs, pancreatic cancers preferentially utiliz... read more here.
Keywords: characterization structure; mutational analysis; biochemical characterization; structure based ... See more keywords
Characterization and Structure of Alternatively Spliced Transcript Variant of Human Intestinal Alkaline Phosphatase (ALPI) Gene.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of nutritional science and vitaminology"
DOI: 10.3177/jnsv.68.284
Abstract: Intestinal-type alkaline phosphatase (IAP) is expressed at a high concentration in the brush border membrane of intestinal epithelial cells and is known to be a gut mucosal defense factor. In humans, a single gene (ALPI)… read more here.
Keywords: alternatively spliced; alpi gene; alkaline phosphatase; gene ... See more keywords
The Characterization of Structure and Prediction for Aquaporin in Tumour Progression by Machine Learning
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.845622
Abstract: Recurrence and new cases of cancer constitute a challenging human health problem. Aquaporins (AQPs) can be expressed in many types of tumours, including the brain, breast, pancreas, colon, skin, ovaries, and lungs, and the histological… read more here.
Keywords: machine; machine learning; prediction; characterization structure ... See more keywords