New quinoxalin‐1,3,4‐oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000471
Abstract: A new series of quinoxalin‐1,3,4‐oxadiazole (10a–l) derivatives was synthesized and evaluated against some metabolic enzymes including human carbonic anhydrase (hCA) isoenzymes I and II (carbonic anhydrases I and II), cholinesterase (acetylcholinesterase and butyrylcholinesterase), and α‐glucosidase.… read more here.
Keywords: oxadiazole derivatives; new quinoxalin; derivatives synthesis; quinoxalin oxadiazole ... See more keywords
Characterization of in vitro generated metabolites of selected peptides
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DOI: 10.1002/dta.2306
Abstract: With an increasing number of prohibited substances in doping controls, knowledge about their metabolism is crucial for efficient analysis. While for low molecular mass molecules, standard protocols for in vitro metabolism experiments are well established,… read more here.
Keywords: metabolites selected; generated metabolites; metabolism; vitro generated ... See more keywords
Optimization, characterization and in vitro/vivo evaluation of azilsartan nanocrystals
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2016.09.008
Abstract: Graphical Abstract Through formulation screening, the irregular-shaped azilsartan nanocrystals were prepared and optimized by bead milling method and solidified by freeze-drying. The best formulation which had the size of 300 nm was expressed in its state… read more here.
Keywords: vitro vivo; azilsartan nanocrystals; azilsartan; characterization vitro ... See more keywords
Preparation, characterization and in vitro activity of a docetaxel-albumin conjugate.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.10.032
Abstract: Docetaxel is one of the most effective anticancer drugs. However, the current formulation of docetaxel contains Tween 80 and ethanol as the solvent, which can cause severe side effects. Consequently, the development of new type… read more here.
Keywords: albumin conjugate; docetaxel albumin; characterization vitro; albumin ... See more keywords
Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.01.044
Abstract: In this research, a polysaccharide fraction (EFSP-1) was obtained from the seeds of Euryale ferox Salisb. by DEAE sepharose FF and Superdex™ 75 gel chromatography. The average molecular weight (Mw) of EFSP-1 was 8.75 kDa. Monosaccharides… read more here.
Keywords: characterization vitro; efsp; euryale ferox; structural characterization ... See more keywords
Characterization, in vitro bioactivity and biological studies of sol-gel synthesized SrO substituted 58S bioactive glass
Sign Up to like & getrecommendations! Published in 2017 at "Ceramics International"
DOI: 10.1016/j.ceramint.2017.08.004
Abstract: Abstract Bioactive glasses (BGs) are considered as a high potential candidate in bone repair and replacement. In the present study, sol–gel derived BGs based on 60% SiO 2 -(36%-x) CaO-4%P 2 O 5 -x SrO… read more here.
Keywords: sol gel; bioactivity; substituted 58s; sro ... See more keywords
Establishment and characterization of an in vitro human small airway model (SmallAir™)
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2016.12.006
Abstract: Graphical abstract Figure. No caption available. ABSTRACT We report here the establishment and characterization of an in vitro human small airway model (SmallAir™). The epithelial cells were isolated from the distal lungs by enzymatic digestion.… read more here.
Keywords: vitro human; human small; model; establishment characterization ... See more keywords
Synthesis, characterization, and in vitro cytotoxicity of a Kiteplatin-Ibuprofen Pt(IV) prodrug
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DOI: 10.1016/j.ica.2017.07.019
Abstract: Abstract The Pt(IV) prodrug of kiteplatin, cis-trans-cis-[PtCl2(RS-Ibuprofen-H)2(cis-1,4-DACH)], having in the axial positions two molecules of Ibuprofen, has been synthesised, characterized and tested in vitro. The aim was to potentiate the cytotoxic effect of kiteplatin with… read more here.
Keywords: anti inflammatory; kiteplatin; characterization vitro; vitro cytotoxicity ... See more keywords
Characterization and in vitro cytotoxic assessment of zinc oxide nano-particles in human epidermoid carcinoma cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of environmental chemical engineering"
DOI: 10.1016/j.jece.2021.105636
Abstract: Abstract The study was designed to evaluate the effect of varying concentrations of ion-carriers on the synthesis of zinc oxide nano-particles (ZONs). We also evaluated the anti-proliferative activity, morphological changes, ROS generation, nuclear apoptosis and… read more here.
Keywords: nano particles; oxide nano; vitro cytotoxic; characterization vitro ... See more keywords
Synthesis and characterization of in vitro properties and biological behavior of Ag/Li co-doped 68S bioactive glass with and without phosphate
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Non-crystalline Solids"
DOI: 10.1016/j.jnoncrysol.2021.121015
Abstract: Abstract This research examined the effect of the presence or absence of phosphate in the chemical composition of Li and Ag co-doped bioactive glass with fixed and optimum amounts of Li and Ag (5 mol.%). The… read more here.
Keywords: synthesis characterization; bioactive glass; glass; characterization vitro ... See more keywords
In-silico designing, chemical synthesis, characterization and in-vitro assessment of antibacterial properties of some analogues of curcumin.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.06.030
Abstract: In the present work two key regulator proteins, monomeric MipZ of Caulobacter vibrioides (similar to Pseudomonas aeruginosa) and Pyruvate kinase of Staphylococcus aureus were docked with curcumin, the wonder molecule from the spice turmeric and… read more here.
Keywords: silico designing; designing chemical; vitro assessment; characterization vitro ... See more keywords