Characterizing the Conformational Dynamics of Human SUMO2: Insights into its Interaction with Metal Ions and SIMs
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DOI: 10.1002/cbic.202400045
Abstract: SUMO (Small Ubiquitin‐like Modifiers) proteins are involved in a crucial post‐translational modification commonly termed as SUMOylation. In this work, we have investigated the native‐state conformational flexibility of human SUMO2 and its interaction with Cu2+ and… read more here.
Keywords: human sumo2; dynamics human; conformational dynamics; sumo2 ... See more keywords
Characterizing conformational states in GPCR structures using machine learning
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DOI: 10.1038/s41598-023-47698-1
Abstract: G protein-coupled receptors (GPCRs) play a pivotal role in signal transduction and represent attractive targets for drug development. Recent advances in structural biology have provided insights into GPCR conformational states, which are critical for understanding… read more here.
Keywords: conformational states; machine; machine learning; gpcr structures ... See more keywords