Characterizing the stabilization effects of stabilizers in protein-protein systems with end-point binding free energy calculations
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DOI: 10.1093/bib/bbac127
Abstract: Drug design targeting protein-protein interactions (PPIs) associated with the development of diseases has been one of the most important therapeutic strategies. Besides interrupting the PPIs with PPI inhibitors/blockers, increasing evidence shows that stabilizing the interaction… read more here.
Keywords: protein protein; stabilization; stabilization effects; characterizing stabilization ... See more keywords