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   Articles with "charge heterogeneity" as a keyword



Application of affinity capillary electrophoresis for charge heterogeneity profiling of biopharmaceuticals

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recommendations! Published in 2019 at "Electrophoresis"

DOI: 10.1002/elps.201900233

Abstract: Charge heterogeneity profiling is important for the quality control (QC) of biopharmaceuticals. Because of the increasing complexity of these therapeutic entities [1], the development of alternative analytical techniques is needed. In this work, flow‐through partial‐filling… read more here.

Keywords: capillary electrophoresis; heterogeneity profiling; charge heterogeneity; electrophoresis ... See more keywords

Characterization of therapeutic mAb charge heterogeneity by iCIEF coupled to mass spectrometry (iCIEF–MS)

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recommendations! Published in 2022 at "ELECTROPHORESIS"

DOI: 10.1002/elps.202200170

Abstract: Imaged capillary isoelectric focusing (iCIEF) has emerged as an important technique for therapeutic monoclonal antibody (mAb) charge heterogeneity analysis in the biopharmaceutical context, providing imaged detection and quantitation by UV without a mobilization step. Besides… read more here.

Keywords: charge; icief; charge heterogeneity; mab charge ... See more keywords

Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry.

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recommendations! Published in 2018 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.8b03773

Abstract: In therapeutic monoclonal antibody (mAb) development, charge heterogeneity of a mAb molecule is often associated with critical quality attributes and is therefore monitored throughout development and during QC release to ensure product and process consistency.… read more here.

Keywords: chromatography; charge heterogeneity; charge; exchange ... See more keywords

Machine learning-driven optimization of culture conditions and media components to mitigate charge heterogeneity in monoclonal antibody production: current advances and future perspectives

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recommendations! Published in 2025 at "mAbs"

DOI: 10.1080/19420862.2025.2547084

Abstract: ABSTRACT Charge heterogeneity in monoclonal antibodies (mAbs), caused by post-translational modifications, remains a substantial obstacle to ensuring consistent, stable, and effective therapeutics. Conventional optimization techniques, such as one-factor-at-a-time and design of experiments, often fail to… read more here.

Keywords: charge heterogeneity; heterogeneity monoclonal; culture; machine learning ... See more keywords

Characterization of the Charge Heterogeneity of a Monoclonal Antibody That Binds to Both Cation Exchange and Anion Exchange Columns under the Same Binding Conditions

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recommendations! Published in 2024 at "Antibodies"

DOI: 10.3390/antib13030052

Abstract: Therapeutic antibodies play an important role in the public healthcare system to treat patients with a variety of diseases. Protein characterization using an array of analytical tools provides in-depth information for drug quality, safety, efficacy,… read more here.

Keywords: exchange columns; anion exchange; antibody; charge heterogeneity ... See more keywords