A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109953
Abstract: Receptor clustering is the first and critical step to activate apoptosis by death receptor-5 (DR5). The recent discovery of the autoinhibitory DR5 ectodomain has challenged the long-standing view of its mechanistic activation by the natural… read more here.
Keywords: residues regulates; dr5 antibodies; positively charged; charged residues ... See more keywords
Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2017.07.003
Abstract: The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous components, including glycosaminoglycans (GAGs). We have shown previously that the GAG low-molecular-weight heparin (LMWH) binds… read more here.
Keywords: charged residues; compatibility glycosaminoglycans; amyloid fibrils; origins compatibility ... See more keywords
Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12040561
Abstract: Intrinsically disordered proteins (IDPs) are ensembles of interconverting conformers whose conformational properties are governed by several physico-chemical factors, including their amino acid composition and the arrangement of oppositely charged residues within the primary structure. In… read more here.
Keywords: intrinsically disordered; shape; charged residues; disordered proteins ... See more keywords
Evidence for Non-Essential Salt Bridges in the M-Gates of Mitochondrial Carrier Proteins
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095060
Abstract: Mitochondrial carriers, which transport metabolites, nucleotides, and cofactors across the mitochondrial inner membrane, have six transmembrane α-helices enclosing a translocation pore with a central substrate binding site whose access is controlled by a cytoplasmic and… read more here.
Keywords: non essential; carrier; charged residues; gate ... See more keywords
Charged Amino Acids Contribute to ZorO Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins15010032
Abstract: Chromosomally encoded toxin-antitoxin systems have been increasingly identified and characterized across bacterial species over the past two decades. Overproduction of the toxin gene results in cell growth stasis or death for the producing cell, but… read more here.
Keywords: charged residues; toxicity; toxin; zoro toxicity ... See more keywords