Development of charybdotoxin Q18F variant as a selective peptide blocker of neuronal BK(α + β4) channel for the treatment of epileptic seizures
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DOI: 10.1002/pro.4506
Abstract: Epilepsy is the results from the imbalance between inhibition and excitation in neural circuits, which is mainly treated by some chemical drugs with side effects. Gain‐of‐function of BK channels or knockout of its β4 subunit… read more here.
Keywords: q18f variant; charybdotoxin; loop; charybdotoxin q18f ... See more keywords