Biosynthesis of Novel Naphthoquinone Derivatives in the Commonly-used Chassis Cells Saccharomyces cerevisiae and Escherichia coli
Sign Up to like & getrecommendations! Published in 2021 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683821100124
Abstract: Naphthoquinones harboring 1,4-naphthoquinone pharmacophore are considered as privileged structures in medicinal chemistry. In pharmaceutical industry and fundamental research, polyketide naphthoquinones were widely produced by heterologous expression of polyketide synthases in microbial chassis cells, such as… read more here.
Keywords: cells saccharomyces; saccharomyces cerevisiae; used chassis; chassis cells ... See more keywords
Systematic Large Fragment Deletions in the Genome of Synechococcus elongatus and the Consequent Changes in Transcriptomic Profiles
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14051091
Abstract: Genome streamlining, as a natural process in the evolution of microbes, has become a common approach for generating ideal chassis cells for synthetic biology studies and industrial applications. However, systematic genome reduction remains a bottleneck… read more here.
Keywords: systematic large; large fragment; genome; synechococcus elongatus ... See more keywords