CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.04.005
Abstract: An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including… read more here.
Keywords: tumor suppressor; chd4; oncogenic functions; chd4 oncogenic ... See more keywords
ZNF410 represses fetal globin by singular control of CHD4.
Sign Up to like & getrecommendations! Published in 2021 at "Nature genetics"
DOI: 10.1038/s41588-021-00843-w
Abstract: Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR screening, we identify zinc-finger protein (ZNF) 410 as an HbF repressor. ZNF410 does not bind… read more here.
Keywords: chd4; fetal globin; represses fetal; globin singular ... See more keywords
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-1049
Abstract: This study identifies CHD4 as a HIF coactivator and elucidates the fundamental mechanism underlying CHD4-mediated HIF transactivation in breast tumors. Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a… read more here.
Keywords: hypoxia; cancer; breast cancer; coactivator ... See more keywords
Missense Mutation in Human CHD4 Causes Ventricular Noncompaction by Repressing ADAMTS1.
Sign Up to like & getrecommendations! Published in 2023 at "Circulation research"
DOI: 10.1161/circresaha.122.322223
Abstract: BACKGROUND Left ventricular noncompaction (LVNC) is a prevalent cardiomyopathy associated with excessive trabeculation and thin compact myocardium. Patients with LVNC are vulnerable to cardiac dysfunction and at high risk of sudden death. Although sporadic and… read more here.
Keywords: ventricular noncompaction; mutation human; missense mutation; chd4 ... See more keywords
The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-22-0011
Abstract: Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function… read more here.
Keywords: chd4; cell function; pdx1; genes involved ... See more keywords
The hsa_circ_0007396-miR-767-3p-CHD4 axis is involved in the progression and carcinogenesis of gastric cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-1218
Abstract: Background Circular RNAs (circRNAs) have been linked to numerous human cancers, including gastric cancer (GC), in numerous recent investigations. The expression of circRNA and the mechanisms involved in GC are still unknown. Methods In this… read more here.
Keywords: hsa circrna; expression; hsa; chd4 ... See more keywords
Over-Expression of CHD4 Is an Independent Biomarker of Poor Prognosis in Patients with Rectal Cancers Receiving Concurrent Chemoradiotherapy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20174087
Abstract: Neoadjuvant concurrent chemoradiotherapy (CCRT), followed by radical proctectomy, is the standard treatment for locally advanced rectal cancer. However, a poor response and therapeutic resistance continue to occur despite this treatment. In this study, we analyzed… read more here.
Keywords: concurrent chemoradiotherapy; chd4; expression; expression chd4 ... See more keywords